Publications

  1. Lopez, C.B.*, Duran, M.*, Virkus, S.A.*, Stocking, S., Yadav, E., Singh, J., Ramsey, V., McMichen, K., Habegger, KM, Hardaway, J.A. Activation of brain stem glucagon neurons encodes frequency-dependent negative valence and reversible reductions in feeding. bioRxiv
  2. Bulik C.M. & Hardaway, J.A., Turning the tide on obesity?. Science. 381,463-463(2023). DOI:10.1126/science.adj9953
  3. Zanella, D., Smith, N., Hardaway, J.A., Buchanan, A.M., Mullins, C.H., Galli, A., Carter, A.M. Bile acids modulate reinstatement of cocaine conditioned place preference and accumbal dopamine dynamics without compromising appetitive learning. Scientific Reports. 2023 Aug 17;13(1):13359. doi: 10.1038/s41598-023-40456-3.
  4. Hon, O.J., DiBerto, J.F., Mazzone, C.M., Sugam, J.A., Bloodgood, D.W., Hardaway, J.A., Husain, M., Kendra, A., McCall, N.M., Lopez, A.L., Kash, T.L.*,Lowery-Gionta, E.G. Serotonin Modulates an Inhibitory Input to the Central Amygdala from the Ventral Periaqueductal Gray. Neuropsychopharmacology. 2022. Dec. 47(13):2194-2204
  5. Bulik, CM, Coleman, JRI, Hardaway, JA, Breithaupt, L, Watson, HJ, Bryant, CD et al.. Genetics and neurobiology of eating disorders. Nat Neurosci. 2022;25 (5):543-554. doi: 10.1038/s41593-022-01071-z. PubMed PMID:35524137 .
  6. Zeng, N, Cutts, EJ, Lopez, CB, Kaur, S, Duran, M, Virkus, SA et al.. Anatomical and Functional Characterization of Central Amygdala Glucagon-Like Peptide 1 Receptor Expressing Neurons. Front Behav Neurosci. 2021;15 :724030. doi: 10.3389/fnbeh.2021.724030. PubMed PMID:35002645 PubMed Central PMC8739476.
  7. Hardaway, JA. Central Amygdala Discovery Efforts in Primates Reveals New Clues on Anxious Temperament. Biol Psychiatry. 2020;88 (8):e35-e36. doi: 10.1016/j.biopsych.2020.07.019. PubMed PMID:32972516 PubMed Central PMC8085899.
  8. Bloodgood, DW, Hardaway, JA, Stanhope, CM, Pati, D, Pina, MM, Neira, S et al.. Kappa opioid receptor and dynorphin signaling in the central amygdala regulates alcohol intake. Mol Psychiatry. 2021;26 (6):2187-2199. doi: 10.1038/s41380-020-0690-z. PubMed PMID:32099099 PubMed Central PMC8124770.
  9. Torruella-Suárez, ML, Vandenberg, JR, Cogan, ES, Tipton, GJ, Teklezghi, A, Dange, K et al.. Manipulations of Central Amygdala Neurotensin Neurons Alter the Consumption of Ethanol and Sweet Fluids in Mice. J Neurosci. 2020;40 (3):632-647. doi: 10.1523/JNEUROSCI.1466-19.2019. PubMed PMID:31744862 PubMed Central PMC6961987.
  10. Hardaway, JA, Halladay, LR, Mazzone, CM, Pati, D, Bloodgood, DW, Kim, M et al.. Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward. Neuron. 2019;102 (5):1088. doi: 10.1016/j.neuron.2019.04.036. PubMed PMID:31170393 PubMed Central PMC6751561.
  11. Robinson, SB, Refai, O, Hardaway, JA, Sturgeon, S, Popay, T, Bermingham, DP et al.. Dopamine-dependent, swimming-induced paralysis arises as a consequence of loss of function mutations in the RUNX transcription factor RNT-1. PLoS One. 2019;14 (5):e0216417. doi: 10.1371/journal.pone.0216417. PubMed PMID:31083672 PubMed Central PMC6513266.
  12. Hardaway, JA, Halladay, LR, Mazzone, CM, Pati, D, Bloodgood, DW, Kim, M et al.. Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward. Neuron. 2019;102 (5):1037-1052.e7. doi: 10.1016/j.neuron.2019.03.037. PubMed PMID:31029403 PubMed Central PMC6750705.
  13. Schaumberg, K, Welch, E, Breithaupt, L, Hübel, C, Baker, JH, Munn-Chernoff, MA et al.. The Science Behind the Academy for Eating Disorders’ Nine Truths About Eating Disorders. Eur Eat Disord Rev. 2017;25 (6):432-450. doi: 10.1002/erv.2553. PubMed PMID:28967161 PubMed Central PMC5711426.
  14. Bermingham, DP, Hardaway, JA, Refai, O, Marks, CR, Snider, SL, Sturgeon, SM et al.. The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters through a Rho-Dependent Mechanism. J Neurosci. 2017;37 (38):9288-9304. doi: 10.1523/JNEUROSCI.1582-17.2017. PubMed PMID:28842414 PubMed Central PMC5607470.
  15. Retzlaff, CL, Kussrow, A, Schorkopf, T, Saetear, P, Bornhop, DJ, Hardaway, JA et al.. Metallo-β-lactamase Domain-Containing Protein 1 (MBLAC1) Is a Specific, High-Affinity Target for the Glutamate Transporter Inducer Ceftriaxone. ACS Chem Neurosci. 2017;8 (10):2132-2138. doi: 10.1021/acschemneuro.7b00232. PubMed PMID:28783953 .
  16. Robinson, SB, Hardaway, JA, Hardie, SL, Wright, J, Glynn, RM, Bermingham, DP et al.. Sequence determinants of the Caenhorhabditis elegans dopamine transporter dictating in vivo axonal export and synaptic localization. Mol Cell Neurosci. 2017;78 :41-51. doi: 10.1016/j.mcn.2016.11.011. PubMed PMID:27913309 PubMed Central PMC5219942.
  17. Marcinkiewcz, CA, Mazzone, CM, D’Agostino, G, Halladay, LR, Hardaway, JA, DiBerto, JF et al.. Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala. Nature. 2016;537 (7618):97-101. doi: 10.1038/nature19318. PubMed PMID:27556938 PubMed Central PMC5124365.
  18. Hardaway, JA, Jensen, J, Kim, M, Mazzone, CM, Sugam, JA, Diberto, JF et al.. Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating. Behav Brain Res. 2016;307 :25-34. doi: 10.1016/j.bbr.2016.03.046. PubMed PMID:27036650 PubMed Central PMC4896639.
  19. Crowley, NA, Bloodgood, DW, Hardaway, JA, Kendra, AM, McCall, JG, Al-Hasani, R et al.. Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit. Cell Rep. 2016;14 (12):2774-83. doi: 10.1016/j.celrep.2016.02.069. PubMed PMID:26997280 PubMed Central PMC4814306.
  20. Bermingham, DP, Hardaway, JA, Snarrenberg, CL, Robinson, SB, Folkes, OM, Salimando, GJ et al.. Acute blockade of the Caenorhabditis elegans dopamine transporter DAT-1 by the mammalian norepinephrine transporter inhibitor nisoxetine reveals the influence of genetic modifications of dopamine signaling in vivo. Neurochem Int. 2016;98 :122-8. doi: 10.1016/j.neuint.2016.01.008. PubMed PMID:26850478 PubMed Central PMC4969213.
  21. Hardaway, JA, Sturgeon, SM, Snarrenberg, CL, Li, Z, Xu, XZ, Bermingham, DP et al.. Glial Expression of the Caenorhabditis elegans Gene swip-10 Supports Glutamate Dependent Control of Extrasynaptic Dopamine Signaling. J Neurosci. 2015;35 (25):9409-23. doi: 10.1523/JNEUROSCI.0800-15.2015. PubMed PMID:26109664 PubMed Central PMC4478255.
  22. Yilmaz, Z, Hardaway, JA, Bulik, CM. Genetics and Epigenetics of Eating Disorders. Adv Genomics Genet. ;5 :131-150. doi: 10.2147/AGG.S55776. PubMed PMID:27013903 PubMed Central PMC4803116.
  23. Kash, TL, Pleil, KE, Marcinkiewcz, CA, Lowery-Gionta, EG, Crowley, N, Mazzone, C et al.. Neuropeptide regulation of signaling and behavior in the BNST. Mol Cells. 2015;38 (1):1-13. doi: 10.14348/molcells.2015.2261. PubMed PMID:25475545 PubMed Central PMC4314126.
  24. Hardaway, JA, Wang, J, Fleming, PA, Fleming, KA, Whitaker, SM, Nackenoff, A et al.. An open-source analytical platform for analysis of C. elegans swimming-induced paralysis. J Neurosci Methods. 2014;232 :58-62. doi: 10.1016/j.jneumeth.2014.04.024. PubMed PMID:24792527 PubMed Central PMC4179448.
  25. Smith, S, Tripathi, R, Goodings, C, Cleveland, S, Mathias, E, Hardaway, JA et al.. LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways. PLoS One. 2014;9 (1):e85883. doi: 10.1371/journal.pone.0085883. PubMed PMID:24465765 PubMed Central PMC3897537.
  26. Hardaway, JA, Hardie, SL, Whitaker, SM, Baas, SR, Zhang, B, Bermingham, DP et al.. Forward genetic analysis to identify determinants of dopamine signaling in Caenorhabditis elegans using swimming-induced paralysis. G3 (Bethesda). 2012;2 (8):961-75. doi: 10.1534/g3.112.003533. PubMed PMID:22908044 PubMed Central PMC3411251.